Analyzing Fine Chemical Production in Plate Reactors

Thomas Forrister June 27, 2018

Batch reactors are used to manufacture a wide variety of products in the fine chemical, pharmaceutical, and food industries. In some cases, fine chemical processing may require more consistent operating conditions than batch reactors can offer, and continuous plate reactors may then provide better control of the process. Chemical modeling can help in the design of continuous plate reactors that are optimized for thermal control and product purity.

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Brianne Costa March 21, 2018

Pablo Rolandi from Amgen delivered a keynote presentation at the COMSOL Conference 2017 Boston. The topic? How Amgen is moving beyond modeling and simulation for biopharma development. Rolandi shared five examples that illustrate this idea across both biologic and synthetic medicine applications. If you missed his presentation, you can watch a recording of the video and read the highlights of what he discussed here.

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Caty Fairclough August 16, 2017

Research shows that microgravity exposure has an effect on the human body, such as by suppressing immune cell activity. This phenomenon also affects cancer cell migration. Making use of this fact can lead to the identification of new therapeutic targets for metastatic cancer cells. In this blog post, we’ll discuss how a research team used the COMSOL Multiphysics® software to design a culturing system to study cancer cell migration in microgravity.

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Claire Bost June 14, 2017

When ambient air flows through porous media, it carries moisture. In this process, temperature and moisture are coupled: The vapor saturates depending on the temperature conditions, while latent heat effects due to evaporation and condensation modify the temperature. We discussed heat and moisture transport in air in a previous blog post. Let’s address the specific transport processes we need to consider in pores and how to model heat and moisture transport in porous media with the COMSOL Multiphysics® software.

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Caty Fairclough December 15, 2016

For patients with renal failure, efficient dialysis treatment is vital. One point of focus is designing high-performance dialysis equipment that increases contaminant removal, improving treatments like hemodialysis. To accomplish this, you can study aspects of the hemodialysis process, such as membrane dialysis devices, with numerical modeling apps. These apps, like the one discussed here, enable users to more quickly analyze the effects of different inputs and improve designs.

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Bridget Paulus November 29, 2016

Transdermal drug delivery (TDD) patches continuously deliver drugs into the body for a certain amount of time. However, the skin is designed to keep out foreign substances, like drugs. To create a TDD patch that successfully bypasses this barrier, simulation can be used to study drug release and absorption into the skin. To analyze this process, Veryst Engineering created a TDD patch model with the COMSOL Multiphysics® software and compared the results to experimental data.

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Caty Fairclough October 19, 2016

In certain food and pharmaceutical industries, different types of dryers are used to dry heat-sensitive products. Vacuum dryers offer one solution for removing water and organic solvents from these sensitive substances. For optimal vacuum dryer design performance, engineers need to balance the dual needs of a rapid drying time and high-quality end products. To achieve this, you can study the vacuum drying process with the COMSOL Multiphysics® software.

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Ed Fontes May 12, 2015

Biosensors are the workhorses of the analytical tools used for detailed mechanistic understanding at the molecular level of biological systems. The applications of these analysis tools are countless for the detection of biomolecules in the pharmaceutical, health care, and food industries; agriculture; environmental technologies; and in general for research of biological systems. The biosensor demo app is a good example of an application where non-experts can benefit from accurate multiphysics simulations.

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Bridget Cunningham March 13, 2015

The biological and chemical processes behind the development of biopharmaceuticals have an important effect on product quality. With its ability to deliver quick results at a lower cost, simulation is a valuable resource in studying and optimizing these techniques. Learn how COMSOL Multiphysics can benefit your modeling of biopharmaceutical processes.

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Fanny Griesmer June 13, 2014

Some chemical applications call for identification and quantification of the components in a chemical mixture. High-performance liquid chromatography (HPLC) is a versatile separation technology for chemical species. To learn more about the separation process, we can model it with simulation software.

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