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Bioscience and Bioengineering

Control-Release Anesthetics to Enable an Integrated Anesthetic-MSC Therapeutic

T. Maguire [1,2], M. Davis [1], I. Marrero-Berrios [1], C. Zhu [1], C. Gaughan [2], J. Weinberg [3], D. Manchikalapati [3], J. SchianodiCola [3], R. S. Schloss [1], J. Yarmush [3], M. Yarmush [1],
[1] Rutgers University, New Brunswick, NJ, USA
[2] BeauRidge Pharmaceuticals, New York, NY, USA
[3] Department of Anesthesiology, New York Methodist Hospital, Brooklyn, NY, USA

Introduction: While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed ... Mehr lesen

Modeling of the Singlet Oxygen Distribution in Photofrin-Photodynamic Therapy of the Plural Cavity

R. Penjweini [1], T. C. Zhu [1], M. M. Kim [1],
[1] Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Photofrin-mediated photodynamic therapy (PDT) is used after surgical resection at the University of Pennsylvania to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rate. When Photofrin is exposed to laser light at 630 nm in well-oxygenated ... Mehr lesen

Simulating Spiking Neurons Using a Simple Mathematical Model

S. Kirigeeganage [1], J. Naber [1], D. Jackson [1], R. Keynton [1], T. Roussel [1],
[1] University of Louisville, Louisville, KY, USA

This paper utilizes COMSOL Multiphysics® software and the Application Builder to simulate neurological responses in nerve axons due to external electrical stimuli. The AC/DC Module of the COMSOL® software is first used to solve the Maxwell's equations. Then the results from the Maxwell's ... Mehr lesen

Using COMSOL Multiphysics® Software for Benchmarking Problems in Cell Migration

M. Nickaeen [1], I. L. Novak [1], A. Mogilner [2], B. M. Slepchenko [1],
[1] Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
[2] Courant Institute and Department of Biology, New York University, New York, NY, USA

A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary ... Mehr lesen

Simulating Fluid Flow through a Culture Chip for Cell Migration Studies in Microgravity

A. Dhall [1], T. Masiello [1], L. Butt [1], M. Strohmayer [1], M. Hemachandra [1], N. Tokranova [1], J. Castracane [1],
[1] Colleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA

Exposure to microgravity is known to alter genomic and proteomic expression and suppress immune cell activity. These changes may influence cancer development. Studying cancer cells in this environment, may help uncover novel therapeutic targets. SUNY Polytechnic Institute and ... Mehr lesen

Highly Sensitive Grating-Coupled Bloch Surface Wave Resonance Biosensor via Azimuthal Interrogation

V. Koju [1], W. M. Robertson [1],
[1] Middle Tennessee State University, Murfreesboro, TN, USA

A dielectric multilayer structure, with a grating profile on the surface layer, can couple light into a strongly confined surface wave, known as a Bloch surface wave. These surface modes can be used to design bio-sensors. The corrugated surface structure also enables azimuthal angular ... Mehr lesen

Numerical Simulation and Thermal Analysis of Tumor in the Human Body

S. Hossain [1], F. A. Mohammadi [1]
[1] Department of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada

INTRODUCTION: Abnormalities in local body surface temperature have been recognized as a sign of disease for centuries, much before humans knew about the cause of ailments or of pain [1]. The idea of this work is to use numerical simulation tools to predict the location, size and ... Mehr lesen

Direct Numerical Simulation of Time Evolution of Vortex Ring

M. Hashiguchi [1],
[1] Keisoku Engineering System Co., Ltd., Chiyoda-ku, Tokyo, Japan

Vortex ring can be useful to generate thrust force for e.g., jellyfish, but its mechanism has not been clarified. In this field, it seems that numerical simulation has an important role of understanding the propulsion mechanism of creature. A vortex ring in a tube, refered to confined ... Mehr lesen

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