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Acoustic Field Comparison of High Intensity Focused Ultrasound Using Experimental Characterization and Finite Element Simulation

J. L. Teja[1], A. Vera[1], L. Leija[1]
[1]Department of Electrical Engineering, Cinvestav-IPN, Mexico D.F., Mexico

High Intensity Focused Ultrasound (HIFU) is used as a noninvasive technique of tissue heating and ablation for different medical treatments. This paper presents a quantitative comparison of HIFU acoustic fields experimentally obtained versus simulated acoustic fields. Acoustic field characterization was realized in two HIFU transducers using water as a propagation medium. Also, simulations were ...

Heat Transfer and Phase Transformation on Matrix Assisted Pulsed Laser Evaporation (MAPLE) of Biocompatible Thin Layers

E. Lacatus[1], G.C. Alecu[1], M.A. Sopronyi[2], A. Tudor[1]
[1]POLITEHNICA University of Bucharest, Bucharest, Romania
[2]INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania

Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique is used for the deposition of high quality biocompatible polymer thin films. During the deposition process the temperature of the laser target should be kept below 193K to assure the proper quality of both evaporation and deposition phases of the process. On a first approach COMSOL Multiphysics® was used to describe and analyze the ...

Rapid Prototyping of Biosensing Surface Plasmon Resonance Devices using COMSOL & Matlab software

J.J. Dubowski[1], and D.Carrier[1]
[1]Department of Electrical and Computer Engineering, Université de Sherbrooke, Quebec, Canada

We present a Finite Element Method simulation procedure that allows rapid development of prototype devices comprising novel self-referenced interference SPR (surface plasmon resonance) biosensing microstructures. The procedure takes advantage of  COMSOL Multiphysics and MATLAB software and their bi-directional link. The simulation is made using COMSOL RF Module, 2D harmonic propagation ...

Analysis of 3D Biocompatible Additive Structure Using COMSOL Multiphysics® Software - new

E. Lacatus[1], M. A. Sopronyi[2], G. C. Alecu[1], A. Tudor[1]
[1]Polytechnic University of Bucharest, Bucharest, Romania
[2]INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania

For biocompatible prosthetics, from dental implants up to bone parts, manufacturers have to find the best way to correlate process parameters and the material properties as to meet the unique needs of individuals. Additive manufacturing techniques aim at creating complex biocompatible structures able to overcome the present shortfalls of the metal and metal alloys implants related to ...

Model of an Interdigitated Electrodes System for Cell Counting Based on Impedance Spectroscopy

E. Bianchi[1][2], F. Bellati[1], E. Rollo[2], G. Dubini[1], C. Guiducci[2]
[1]Politecnico di Milano, LaBS, Laboratory of Biological Structure Mechanics, Milano, Italy
[2]Swiss Federal Institute of Technology (EPFL), Laboratory of Life Sciences Electronics - Swiss Up Chair, Lausanne, Switzerland

A model of a cell counter sensor based on Impedance Spectroscopy (IS) has been implemented in COMSOL Multiphysics. The cell counter is a silicon-based microdevice consisting in 3D electrodes placed in a wide microchannel: cells flow in the microchannel through the electrodes to be detected. The model allows to evaluate the functionality of the device depending on geometrical parameters and ...

Stochastic Diffusion of Calcium Ions Through a Nanopore in the Cell Membrane Created by Electroporation - new

O. Henao[1], V. Gómez[1], I. De La Pava[1], J. Sánchez [1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

We simulated the diffusion of calcium ions through a nanopore created in the cell membrane by electroporation, in presence and absence of the external electric field responsible of the membrane permeabilization. First we solved the set of coupled differential equations that describe the process of ionic diffusion in a 2D nanopore model using the AC/DC Module and the Transport of Diluted Species ...

Modeling Drug Release from Materials Based on Electrospun Nanofibers

P. Nakielski[1], T. Kowalczyk[1], T.A. Kowalewski[1]
[1]Institute of Fundamental Technological Research Polish Academy of Sciences, Warsaw, Poland

Comprehensive studies of drug transport in nanofibres based mats have been performed to predict drug release kinetics. The paper presents our approach to analyze the impact of fibers arrangement, one of the parameters varied in our parallel experimental studies. COMSOL Multiphysics® has been used to assess the impact of the various purposed arrangements of fibers within the mat. Drug release ...

Multiphysics Modeling and Analysis of DBS Electrodes: Application to Parkinson’s Disease

M.Vidya[1], M. SharatDivya[1], N.Priyadarshini[1], E.R Rajkumar[1]
[1]Division of Biomedical Engineering, Center for Biomedical Engineering Research, School Of Biosciences and Technology, VIT University Vellore, India.

Deep Brain Stimulation (DBS) is a surgical technique that involves surgically implanting Platinum electrode to create an electric field to activate the targeted nerve cells and fibers with minimized side effects. Important stimulation parameters to monitor include temperature, electric field intensity and the current density.This paper gives a Finite Element Model (FEM) for DBS electrode in ...

Computational Analysis on Commercially Available Stent Designs

K. Basu[1], P. Ghosh[2], S. Bhattacharjee[2], S. Das [2], A. Chanda[1]
[1]School of Bio Science and Engineering, Jadavpur University, Kolkata, West Bengal, India
[2]Department of Mechanical Engineering, Jadavpur University, Kolkata, West Bengal, India

Cardiovascular disease has become a major healthcare problem. To tackle this along with bypass surgery, the use of the cardiovascular stent is considered promising and effective. In this study, we aim to find the effectiveness of stent deployments and their influence on haemodynamics post their deployment in human arteries. For the study we have reconstructed single units of two commercially ...

Calibration of a Bio-Kinetic Model to Simulate Microalgae Growth - new

A. Solimeno[1], J. Garcia[2]
[1]Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
[2]Universitat Politecnica de Catalunya, Barcelona, Spain

The aim of present work is to present and calibrate a new mechanistic model that includes physical and biokinetic processes to reproduce the algae growth in photobioreactor or ponds during long-term scenarios. A COMSOL Multiphysics® model is used to implement the microalgae processes mainly based on River Water Quality Model 1 (RWQM1) (Reichert et al., 2011). The main innovation of the model is ...