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Coupled PDEs with Initial Solution from Data in COMSOL Multiphysics®

M. K. Gobbert[1], X. Huang[1], S. Khuvis[1], S. Askarian[1], B. E. Peercy[1]
[1]University of Maryland - Baltimore County, Baltimore, MD, USA

This paper presents information on techniques needed in COMSOL Multiphysics® to enable computational studies of coupled systems of PDEs for time-dependent non-linear problems. Furthermore, we demonstrate how to use data files as input for initial conditions. To illustrate the techniques, we consider a system of two time-dependent non-linear PDEs from mathematical biology that couples an ...

Modeling the Behavior of Phased Arrays in Brain Tissue: Application to Deep Brain Stimulation

V. Valente[1], A. Demosthenous[1], and R. Bayford[2]

[1]Department of Electronic & Electrical Engineering, University College London, London, United Kingdom
[2]Department of Natural Sciences, Middlesex University, London, United Kingdom

Deep Brain Stimulation (DBS) is a therapeutic tool used for a number of neurological disorders including chronic pain, incontinence and movement disorders, such as Parkinson’s disease. DBS consists of the low-frequency stimulation of an area of the brain, known as basal ganglia. The stimulation is provided by clinical implant, consisting of a pulse generator and an electrode lead ...

Models for Simulation Based Selection of 3D Multilayered Graphene Biosensors

E. Lacatus [1], G. C. Alecu [1], A. Tudor [1],
[1] Politehnica University of Bucharest, București, Romania

At the forefront of a new generation of sensors graphene and graphene composite materials are intensively studied for medical and biosensing applications. The outstanding electrical, mechanical and quantum properties of graphene make them a promising material solution to overlap the existing gap between biological and non-biological systems into a continuum like-viscoelastic integrated model. ...

Modeling of an Oxygenation-Aided 3D Culture for Functional Beta-Cell Expansion

S. Jin[1], J. McReynolds[1], X. Li[2], J. Guan[2]
[1]Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, AR, USA
[2]Department of Materials Science and Engineering, The Ohio State University, Columbus, OH, USA

Currently, researchers are looking for ways to mass-produce biologically functional pancreatic beta cells in vitro because of the shortage of donor tissue needed for diabetes cell therapy. The beta cells will become hypoxic if their high oxygen demands are not met. We hypothesized that the biological function of beta cells can be improved if they are cultured in a 3D collagen scaffold, which ...

Finite Element Analysis of Equine Tooth Movement Under Masticatory Loading

M. Gardemin[1], M. Lüpke[1], V. Cordes[2], and C. Staszyk[2]
[1]Institute for General Radiology and Medical Physics, University of Veterinary Medicine Hannover, Hannover, Germany
[2]Institute of Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany

Like humans, horses can develop a variety of dental problems. Different equine diseases occur in different areas of the equine cheek tooth or its surrounding tissues. With a realistic simulation of a chewing cycle it can be possible to link mechanical phenomena such as high stress in distinct areas to commonly occurring diseases. According to different angles of the acting chewing force, ...

Thin Membrane Modelling for the Electrical Stimulation of Auditory Nerve

A. Grünbaum[1], S. Petersen[1], H.W. Pau[2], and U. van Rienen[1]

[1]IEF funded by DFG Research Training Group 1505/1 Welisa, University of Rostock, Rostock, Germany
[2]Otolaryngology “Otto Körner”, University of Rostock, Rostock, Germany

Modeling of 2-5 μm thin membranes into a cochlea with a width of 2 cm is computationally. The paper is focused on two approximative methods used to overcome this problem and in addition a simple model challenging of a plate capacitor with a thin membrane of different thickness in-between is presented. The results of simulations with both thin layer approximation methods are compared with ...

A Practical Method to Model Complex Three-Dimensional Geometries with Non-Uniform Material Properties Using Image-based Design and COMSOL Multiphysics®

J. Cepeda[1], S. Birla[2], J. Subbiah[2], H. Thippareddi[1]
[1]Department of Food Science & Technology, University of Nebraska, Lincoln, NE, USA
[2]Department of Biological Systems Engineering, University of Nebraska, Lincoln, NE, USA

Geometries with heterogeneous material properties are typically defined as a set of multiple parts, each part representing a different material. However, assembling or defining the individual parts of complex geometries can be difficult. A practical method based on image-based mesh generation, a custom algorithm for labeling materials, and interpolation functions of COMSOL Multiphysics® can be ...

Finite Element Analysis of Microscale Luminescent Glucose Sensors in the Skin Dermis

S. Ali[1], and M. McShane[1]
[1]Department of Biomedical Engineering, Texas A&M University-College Station, Texas, USA

With the rising predominance of diabetes, successful management of blood glucose levels is increasingly important. Key efforts have focused on the development of optical microscale glucose sensing systems based on the encapsulation of glucose oxidase within microspheres coated with polyelectrolyte multilayer nanofilms. A two-substrate mathematical model of microscale optical glucose sensors in ...

Heat and Mass Transfer in Convective Drying Processes

C. Gavrila[1], A. Ghiaus[1], and I. Gruia[2]
[1]Technical University of Civil Engineering Bucharest, Faculty of Building Services, Bucharest, Romania
[2]University of Bucharest, Faculty of Physics, Bucharest, Romania

A dynamic mathematical model, based on physical and transport properties and mass and energy balances, was developed for the simulation of unsteady convective drying of agricultural products (fruits and vegetables) in static bed conditions. The model utilizes water sorption isotherm equations and the change in solid density due to the shrinkage phenomenon. The aim of this article is to describe ...

Growth and Remodelling of Intracranial Saccular Aneurysms

A. Di Carlo[1], V. Sansalone[2], A. Tatone[3], and V. Varano[1]
[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
[3]DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy

We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...