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Study of Fluid and Mass Adsorption Model in the QCM-D Sensor for Characterization of Biomolecular Interaction

H.J. Kwon[1], C.K. Bradfield[1], B.T. Dodge[1], and G.S. Agoki[1]
[1]Department of Engineering and Computer Science, Andrews University, Berrien Springs, Michigan, USA

Increasing attention has been paid to application of the quartz crystal microbalance with dissipation (QCM-D) sensor for monitoring biomolecular interactions. This paper focuses on a practical application of protein-protein binding affinity measurement at low concentrations and minimal sample sizes (50-200 μl of 20-200 nM), which results in low signal measurement. A model simulating fluid ...

Dynamic Simulation of Electrochemical Etching of Silicon with COMSOL

A. Ivanov[1], U. Mescheder[1]
[1]Furtwangen University, Furtwangen, Germany

In the presented work the dynamic simulation of a silicon anodization process is performed. Two mechanisms of etch form development (diffusion in electrolyte, current flow) are considered and simulated. Influence of electrolyte conductivity and radius of the opening in the masking layer is discussed.

Design of MEMS based Polymer Microphone for Hearing Aid Application

V. S. Nagaraja[1], Ramanuja H. S.[1], Deepak K[1], S. L. Pinjare[1]
[1]Electronics and Communication Engineering, Nitte Meenakshi Institute of Technology, Bangalore, Karnataka, India

In this work, a MEMS based condenser microphone [1,2] using Polyimide as the diaphragm has been designed. The microphone structure has a backplate placed on top of the diaphragm. The backplate and the diaphragm are made up of polyimide. The two polyimide plates are separated by air gap which is achieved by using Aluminium as a sacrificial layer in between, which is etched away to create the air ...

Near-Wall Dynamics of Microbubbles in an Acoustical Trap - new

L. Wright[1], G. Memoli[1], P. Jones[2], E. Stride[3]
[1]National Physical Laboratory, Teddington, UK
[2]University College London, London, UK
[3]University of Oxford, Oxford, UK

Understanding the interactions between microbubbles and surfaces is key to the successful deployment of microbubbles in a range of applications. Two important examples are their use as a drug delivery mechanism, and their potential use of acoustically-driven bubbles as microscale sensors. Drug delivery with bubbles involves sonication at high frequency close to a boundary, and sensing with ...

The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes

G. Zhang[1][,][2][,][3], S.L. Bearden [1]
[1]Department of Bioengineering, Clemson University, Clemson, SC, USA
[2]Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
[3]Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA

Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...

3D-Modeling of Magnetophoretic Separation of Superparamagnetic Dispersions Using COMSOL Multiphysics® Particle Tracing Module

D. Kleinehanding[1], L. Teich[1], C. Schröder[1]
[1]Department of Engineering Sciences and Mathematics, Computational Materials Science & Engineering (CMSE), University of Applied Sciences Bielefeld, Bielefeld, Germany

Magnetophoresis is a process of great interest for novel applications based on magnetic nanoparticles and colloids. Environmental applications like wastewater treatments and pollutant removal, biomedical applications like protein isolation, drug delivery, magnetic hyperthermia for cancer treatment, and magnetic-particle imaging are just a few of the numerous technological areas which exploit the ...

Polymer Nanowire based Impedance Biosensor

N. Das[1], C. R. Chaudhuri[1]
[1]Department of Electronics and Telecommunication, BESUS, Howrah, West Bengal, India

In this paper, we have proposed an impedance biosensor based on polymer nanowire (made of polyaniline) for efficient electric field mediated capture of biomolecules. Existing polymer nanowire based biosensors fail to achieve high sensitivity for low surface to volume ratio as the whole length of the nanowire is exposed to the analyte .Also biosensors are dependent on diffusion mediated capture ...

Analyte Capture from Liquid Samples: Size Matters

M. Weber[1], M. Reed[1]
[1]Yale University, New Haven, CT, USA

Arrays of vertical pillars, Micro Purification Chips, have been widely used for analyte capture from liquid samples [Henderson et. al, 2006], [Toner et. al, 2007], [Stern et. al, 2010]. However exact understanding of the capture efficiency mechanisms has not been previously explained. Here we present a model in COMSOL Multiphysics® which calculates analyte capture efficiency based on initial ...

The Origin of Mass-change Sensitivity within Multi-layered, Non-uniform, Piezoelectrically-actuated Millimeter-sized Cantilever (PEMC) Biosensors: Vibrational Analysis through Experiment and Finite Element Modeling (FEM)

B.N. Johnson[1], and R. Mutharasan[1]

[1]Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania, USA

A 3D finite element model (FEM) of the PEMC sensor was developed to characterize the modes of vibration that have demonstrated high sensitivity to mass-change in experimentally fabricated sensors. The fundamental bending mode of vibration and the 1st bending harmonic are predicted at 10.0 kHz and 86.8 kHz, respectively, within approximately 5 % of the experimentally measured resonances. The ...

Xylophone Bar Magnetometry and Inertial-grade MEMS Optimisation: a Multiphysics Approach

H. T. D. Grigg, and B. J. Gallacher
Microsystems Group
Newcastle University
Newcastle upon Tyne
Tyne and Wear, UK

This paper presents ongoing research aimed at development of a MEMS magnetometer capable of nanoTesla sensitivity. Such a device would pave the way for inertial-grade MEMS IMUs. A resonant sensor is proposed, based on a Xylophone Bar sense element, and is analysed both directly and via COMSOL. Mode shapes and frequencies are found as functions of geometric parameters, and the results used ...