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Suchbegriff:

Strong Localization and Rapid Time Scales of Superheating in Solid-State Nanopores

E. Levine[1], G. Nagashima[1], D. Hoogerheide[1], M. Burns[2], J. Golovchenko[1]
[1]Harvard University, Cambridge, MA, USA
[2]Rowland Institute at Harvard University, Cambridge, MA, USA

Extreme localized superheating and homogeneous vapor bubble nucleation have recently been demonstrated in a single nanopore in thin, solid state membranes [1]. Aqueous electrolytic solution present within the pore is superheated to well above its boiling point by Joule heating from ionic ... Mehr lesen

Design and Simulation of High-Throughput Microfluidic Droplet Dispenser for Lab-on-a-Chip Applications

C. Jin[1], X. Xiong[2], P. Patra[1], R. Zhu[1], J. Hu[3]
[1]Department of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, USA
[2]Department of Electrical and Computer Engineering, University of Bridgeport, Bridgeport, CT, USA
[3]Department of Mechanical Engineering, University of Bridgeport, Bridgeport, CT, USA

Digital Microfluidic Biochip (DMFB) has been widely used in Lab-on-a-Chip (LoC) for disease diagnosis and treatment applications. To quickly convert traditional analog fluidic sample into digital droplets for DMFB processing, a high-throughput microfluidic droplet dispenser device is ... Mehr lesen

Digital Microfluidic Droplet Adapter for Interconnection of Biochips

R. Zhu[1], X. Xiong[2], P. Patra[1], C. Jin[1], J. Hu[3]
[1]Department of Biomedical Engineering, University of Bridgeport, Bridgeport, CT, USA
[2]Department of Electrical & Computer Engineering, University of Bridgeport, Bridgeport, CT, USA
[3]Department of Mechanical Engineering, University of Bridgeport, Bridgeport, CT, USA

In this research, we use the COMSOL Multiphysics® software to design and simulate a digital microfluidic droplet adapter for board-level biochip integration. Digital Microfluidic Biochip (DMFB) has gained tremendous research interest in recent years due to its importance in Lab-on-a-Chip ... Mehr lesen

Fluid Leakage Across a Pressure Seal

R. P. Ruby[1], G. Kulkarni[2], U. Kanade[1]
[1]Noumenon Multiphysics Pvt. Ltd., Pune, Maharashtra, India
[2]Oneirix Engineering Laboratories Pvt. Ltd., Pune, Maharashtra, India

Seals or gaskets that are compressed between walls of a container are important to many industrial applications. In this paper we present a fluid flow model for predicting the sealing performance of such seals. A computational study using COMSOL Multiphysics® software suggests very ... Mehr lesen

Simulation of Droplet Impingement on a Solid Surface by the Level Set Method

J. Hu[1], R. Jia[1], K. Wan[2], X. Xiong[3]
[1]Department of Mechanical Engineering, University of Bridgeport, Bridgeport, CT, USA
[2]Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA
[3]Department of Electrical Engineering, University of Bridgeport, Bridgeport, CT, USA

The dynamic behavior of droplet impingement on a solid surface is important to many engineering applications. This paper studied the dynamic behavior of a droplet impinging onto solid dry surfaces with different surface wettability using the COMSOL Multiphysics® software. The simulation ... Mehr lesen

Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties

K. Cluff[1], H. Mehraein[1], G. Jayakumar[2]
[1]Bioengineering, Wichita State University, Wichita, KS, USA
[2]Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical ... Mehr lesen

Analysis of Heat Transfer in a Complex Three Dimensional Structure Fabricated by Additive Manufacturing

C. Settle[1], K. Hoshino[1]
[1]Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA

The goal of this study was to create a three dimensionally designed biomedical device with multiple functionalities and analyze its simulated heat transfer. The device would be fabricated through additive manufacturing; specifically electron beam melting (EBM). EBM has a feature size ... Mehr lesen

Simulation of Gravity-Driven Flow Through a Microfluidic Device on a Rocker Platform

B. Srinivasan[1], J. Hickman[1], M. Shuler[2]
[1]University of Central Florida, Orlando, FL, USA
[2]Cornell University, Ithaca, NY, USA

A micropump delivers fluid between different components of a microfluidic device in a controlled manner. The elimination of micropump can reduce the design complexity, simplify fabrication, shrink the device footprint and decrease the set-up time required for the operation of the ... Mehr lesen

DNA Interactions in Crowded Nanopores

K. Misiunas[1], N. Laohakunakorn[1], S. Ghosal[2], O. Otto[1], U. F. Keyser[1]
[1]University of Cambridge, Cambridge, UK
[2]Northwestern University, Evanston, IL, USA

The motion of DNA in crowded environments is a common theme in physics and biology. Examples include gel electrophoresis and the self-interaction of DNA within cells and viral capsids. Here we study the interaction of multiple DNA molecules within a nanopore by tethering the DNA to a ... Mehr lesen

Optimization of the Herringbone Type Micromixer Using Numerical Modelling and Validation by Measurements

E. Tóth[1], K. Iván[1], P. Fürjes[2]
[1]Pázmány Péter Catholic University, Budapest, Hungary
[2]Research Centre for Natural Sciences Institute for Technical Physics and Materials Science Hungarian Academy of Sciences, Budapest, Hungary

COMSOL Multiphysics® software was used in this study to simulate mixing by diffusion and by secondary flow. Particle tracing model was applied to simulate the mixing of cells in the microchannel. Results agreed well with the measurement, an optimal herring-bone structure was proposed for ... Mehr lesen

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