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Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new

L. Saeeednia[1], H. Mehraein[2], F. Abedin[1], K. Cluff[2], R. Asmatulu[1]
[1]Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
[2]Department of Bioengineering, Wichita State University, Wichita, KS, USA

Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...

Multiphysics: Fluid Mixing and Brine Pool Formation for Economic Geology Applications - new

C. Schardt[1]
[1]University of Minnesota-Duluth, Duluth, MN, USA

Significant submarine mineral deposits form when hot, metal-laden, saline fluids emerge onto the seafloor and mix with ambient seawater. Resulting density changes of fluid mixtures can trigger fluid buoyancy reversals, brine pool formation, and metal accumulation (Figure 1). While some of these processes are known from experiments, the inception, development, and physical-chemical processes ...

Simulation of Manufacturing Process of Ceramic Matrix Composites

S. Yushanov, J. Crompton, and K. Koppenhoefer
ACES of Columbus, LLC, Columbus, OH, USA

Improved performance of aeroengines requires the development of new manufacturing technologies for ceramic matrix composites (CMCs). This has been simulated using COMSOL Multiphysics. Specialized simulation technologies have been developed to describe the infiltration of molten material into a ceramic perform. The physical phenomena considered in the analysis includes: unsaturated flow, ...

Catalytic Pellet Based Heterocatalytic Reactor Bed Models Development

G. Rádi, T. Varga, and T. Chován
University of Pannonia, Veszprem, Hungary

Nowadays mathematical models are applied in almost every field of our life to predict how real systems behave. Computational Fluid Dynamics (CFD) has become a standard tool for analyzing various situations where fluid flow has a significant effect on the studied processes. Complex models can be implemented and solved in commercial CFD packages (e.g. COMSOL Multiphysics). The goal of this paper ...

Experimental Validation of Model of Electro-Chemical-Mechanical Planarization (ECMP) of Copper

J. Ebert[1], S. Ghosal[1], A. Emami-Naeini[1]
[1]SC Solutions, Sunnyvale, CA, USA

This paper describes the development of a COMSOL model of Electro-Chemical-Mechanical Planarization (ECMP) that was validated with experimental data. ECMP is used for processing of semiconductor wafers. We developed a 2D model of flow of phosphoric acid solution (the electrolyte) between two parallel plates that focuses on the physics and electrochemistry in ECMP. The model includes steady-state ...

Numerical Study and Simulation in COMSOL Multiphysics of the Dilution Process during Dust Sampling in Dry Machining

B. Wenga-Ntcheping[1], A. Djebara[1], R. Kamguem[1], J. Kouam[1], V. Songmene[1]
[1]University of Quebec-École de Technologie Supérieure, Montreal, Canada

Dilution’s issue during dry machining have raised the interest’s environmental researchers and engineers. In fact, the sampling of dust emitted during dry machining was a serious problem for air quality evaluation at the workplace. Furthermore, the best sampling of fine and ultrafine particles produced during material cutting, passed through the dilution of high particle concentration (number, ...

A Virtual Laboratory for the 4 Bed Molecular Sieve of the Carbon Dioxide Removal Assembly

R. Coker [1], J. Knox [1], B. O'Connor [1],
[1] Marshall Space Flight Center - NASA, Huntsville, AL, USA

Introduction: Ongoing work to improve water and carbon dioxide separation systems to be used on crewed space vehicles combines sub-scale systems testing and multi-physics simulations. Thus, as part of NASA’s Advanced Exploration Systems (AES) program and the Life Support Systems Project (LSSP), fully predictive COMSOL Multiphysics® software models of the Four Bed Molecular Sieve (4BMS) of the ...

COMSOL application in modeling PEMFC transients

X. Li
Chinese Academy of Sciences, Dalian Institute of Chemical Physics, Beijing, China

We studied the transient characteristics of PEMFC and water transport during PEMFC start-up, concerning the following aspects: Effect of air stoichiometry change on transient behavior of PEMFC, Transient behavior of water transport during PEMFC start-up, and high temperature PEMFC modeling.

Diffuse Interface Models for Metal Foams

B. Chinè[1], M. Monno[2], E. Repossi[3], M. Verani[3]
[1]Laboratorio MUSP Piacenza, Italy; ITCR, Esc. Ciencia e Ing. Materiales, Cartago, Costa Rica
[2]Laboratorio MUSP, Piacenza, Italy; Politecnico di Milano, Dip. Meccanica, Milano, Italy
[3]Politecnico di Milano, MOX-Dip. Matematica, Milano, Italy

The foaming process of a metal is a complex operation which needs to be closely controlled in order to guarantee the wanted properties, by avoiding the formation of defects in the structure of the material. In this work we use COMSOL Multiphysics® version 4.3b and apply the diffuse interface methods of the phase field technique available in the CFD module.To analyze a practical case, foams ...

Development of a Multiphase, Multispecies Droplet Evaporation Model for Optimization of Desiccation Preservation Techniques

A. Sinkevich[1], S. Bhowmick [1], M. Raessi[1]
[1]University of Massachusetts Dartmouth, North Dartmouth, MA, USA

Biopreservation deals with the protection and storage of complex biologics such as proteins, lipids, and recently, mammalian cells. One preservation method, known as lyopreservation, involves placing a biologic inside a water droplet with some type of sugar excipient (sucrose, trehalose, etc.) and drying the solution convectively. We are currently developing a model that couples the two-phase ...