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Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface

F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Palaiseau, France

Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...

Two Dimensional Blood Shear Modeling in a Blood Cooling Catheter

R. Sikorski[1], B. Chapman[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...

COMSOL Multiphysics® Model of Canine Elbow for Use in Investigating Medial Coronoid Disease

K. A. Bodnyk[1], G. J. Noble[1], N. Fitzpatrick[2], M. J. Allen[3], K. Stephenoff[1], R. T. Hart[1]
[1]Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
[2]Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
[3]Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA

The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...

Design and Optimization of Cholesterol Biosensor

N. M. Sundaram[1], M. Alagappan[1]
[1]PSG College of Technology Coimbatore, Tamil Nadu, India

Cholesterol is an essential lipid for human body. The desired total plasma cholesterol for an individual is less than 5.2 mM (200 mg/dL) and it poses a potential health threat when the level is greater than 6.2 mM (240 mg/dL) [1]. Excessive plasma cholesterol causes poor cardiovascular conditions. The experimental fabrication of nano structured biosensor with advanced materials is more expensive ...

Drop Simulation of Disposable Elastomeric Pump Using COMSOL Multiphysics® Software

R. Kapuganti [1], S. Anbazhagan[1],
[1] HCL Technologies, Chennai, India.

Drop test simulation is one of the important tool used for the impact behaviour study of electronic components. It identifies the flaws in design. The reliability and performance of electronic consoles after the drop is a major concern. Devices are expected to continue functioning after suffering a drop. The model is allowed to fall freely due to gravity load application. Drop test standard ...

A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry

Kristian Dreij[1], Qasim Ali Chaudhry[2], Bengt Jernström[1], Ralf Morgenstern[1], and Michael Hanke[2]
[1]Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
[2]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden

A general description of effects of toxic compounds in mammalian cells is facing several problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly influence their behaviour. Secondly, cells display considerable heterogeneity regarding the presence, activity and distribution of enzymes participating in the metabolism of foreign compounds i.e. bioactivation ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Optimization of Device Geometry of a Fully-Implantable Hearing Aid Microphone

A. Dwivedi [1], G. Khanna [1],
[1] National Institute of Technology Hamirpur, Himachal Pradesh, India

The hearing impairment is affecting more than 360 million people all over the world.In India alone, 63 million people suffer from the significant auditory loss. Conventional hearing aids suffer from reliability, practicality and social stigma concerns. The totally implantable devices provide freedom from the social and practical difficulties of using conventional hearing aids. The paper presents ...

Numerical Simulation and Thermal Analysis of Tumor in the Human Body

S. Hossain [1], F. A. Mohammadi [1]
[1] Department of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada

INTRODUCTION: Abnormalities in local body surface temperature have been recognized as a sign of disease for centuries, much before humans knew about the cause of ailments or of pain [1]. The idea of this work is to use numerical simulation tools to predict the location, size and metabolism of tumor embedded in any outer body organ of human. Idealized thermal data of an organ, modeled either as a ...

Simulating Organogenesis in COMSOL

D. Iber, D. Menshykau, and P. Germann
ETH Zürich
Department of Biosystems Science and Engineering
Basel, Switzerland

Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...