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Numerical Simulations Demonstrate Safe Vitrification and Warming of Embryos Using the Rapid-i™ Device

B.O.J. Johansson[1][2], Y.A. Tarakanov[1], H.J. Lehmann[2], and S.P. Apell[1]

[1]Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
[2]Vitrolife Sweden AB, Västra Frölunda, Sweden

During cryopreservation of human embryos, ice crystal formation in the embryos or in surrounding media may cause cryodamage to them and can be lethal. A strategy to avoid this is the vitrification procedure when the embryo and the surrounding medium undergo the transition to glassy state rather than a crystalline one during cooling. Similarly, recrystallization in the embryo or the medium must ...

Simulating Microbubble Flows Using COMSOL Multiphysics

X. Chen[1], and S. Ghadiali[1,2]

[1]Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, USA
[2]Bio Engineering program, Lehigh University, Bethlehem, PA, USA

Acute respiratory distress syndrome (ARDS) is a severe lung disease caused by a variety of direct and indirect insults. The main treatment for ARDS is mechanical ventilation. The ventilation of fluid filled lungs involves the propagation of microbubbles over a layer of epithelial cells. We utilized COMSOL® with MATLAB® to develop a time dependent computational model of semi-infinite air ...

3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®

X.G. Li[1], H. von Holst[1][2], J. Ho[1], and S. Kleiven[1]

[1]Division of Neuronic Engineering, KTH, Stockholm, Sweden
[2]Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...

Modeling of Tumor Location Effect in Breast Microwave Imaging using COMSOL

E. Khosrowshahli[1], and A. Jeremic[2]
[1]School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada
[2]McMaster University, Dept. of Electrical and Computer Engineering, McMaster University,
Hamilton, ON, Canada

Microwave imaging has been recently proposed as a potentially useful screening technique for breast cancer. This method detects abnormalities in the tissue based on permittivity difference between breast normal and malignant tissue. In this method breast is illuminated by high frequency electromagnetic wave, and received waves are then analyzed in order to construct a map of breast\'s ...

Dynamic Simulation of Bone Morphogenetic Protein Patterning in a 3D Finite-Element Model of the Danio Rerio Embryo

D. Umulis, and S. Lee
Purdue University
West Lafayette, IN

Zebrafish development of the dorsoventral axis relies on the spatiotemporal distribution of Bone Morphogenetic Protein (BMP) signaling, which is regulated by numerous secreted molecules such as Tolloid, Sizzled, and Chordin. The rich dorsal/ventral patterning network must achieve both spatial precision in the patterning of downstream targets and confernspatial precision at distinct time points ...

Modeling Phytoremediation by Mangroves

O. Richter[1], H. Anh Nguyen[1], V. Phuoc Nguyen[2]
[1]Institute of Geoecology, University of Technology Braunschweig, Germany
[2]Institute for Environment & Resources, HCM-City, Vietnam

Metal contaminants and organic pollutants are affecting aquatic environments in urban and industrial zones. Mangrove trees are capable of absorbing metal ions and organic pollutants. To estimate the remediation potential, a two dimensional model of water and substance flow in the soil plant system based on porous media equations was set up. We show that multiphysics approaches also apply to ...

A Model of Noninvasive Radiofrequency Tissue Heating

L. Rems[1], D. Miklavcic[1]
[1]University of Ljubljana, Faculty of Electrical Engineering, Ljubljana, Slovenia

Noninvasive radiofrequency (RF) tissue heating is frequently used for skin tightening and facial wrinkle reduction as alternative to invasive surgical procedures. However, to ensure a safe and efficient therapy, the temperature of the skin and the subcutaneous tissue must be controlled in order to prevent tissue damage. We used numerical modeling to investigate the dynamics of the temperature ...

Evaluation of Binary Mixture Models for 3D Printed Biosensors

J. Persad [1], S. Rocke [1], D. Ringis [1], A. Abdool [1],
[1] Department of Electrical and Computer Engineering, University of the West Indies, St. Augustine, Trinidad and Tobago

3D printing as applied to the area of electronics manufacture covers a broad range of traditional printing technologies [1]. The attraction in 3D printing lies in its potential to disrupt the traditional photolithographic/subtractive manufacturing line with simpler additive processes. Additive electronics manufacturing which utilises 3D printing techniques allow for fewer production steps and ...

Virtual Thermal Ablation in the Head and Neck using COMSOL Multiphysics

U. Topaloglu[1], Y. Yan[2], P. Novak[2], P. Spring[3], J. Suen[3], and G. Shafirstein[3]
[1] Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[2]Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[3]Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...

Fresh Produce Safety During Hydrocooling: An Engineering Model - new

A. Warning[1], A. K. Datta[1]
[1]Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA

Hydrocooling is the process by which warm produce is chilled with water. The chilling of warm produce generates a negative pressure differential between the produce (warm) and (cold) water due to the condensation of water vapor inside the produce which forms a vacuum and can pull in contaminated water through an opening. A porous media based model of water infiltration was developed using a ...