P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
R. Santoprete, B. Querleux
L'Oréal, Paris, France
To better quantify the impact of the morphological and mechanical properties of the main constituents of the stratum corneum (SC, the outermost layer of the skin) on its overall mechanical behavior, we developed a biomechanical model of the SC at a cellular scale, based on in vitro morphological and mechanical data. The sensitivity analysis quantified the relative impact of the mechanical and ...
Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new
L. Saeeednia, H. Mehraein, F. Abedin, K. Cluff, R. Asmatulu
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...
3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®
X.G. Li, H. von Holst, J. Ho, and S. Kleiven
Division of Neuronic Engineering, KTH, Stockholm, Sweden
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...
Simulation of a Magnetic Induction Method for Determining Passive Electrical Property Changes of Human Trunk Due to Vital Activities
H. Mahdavi, J. Rosell Ferrer
Universitat Politècnica de Catalunya, Barcelona, Spain
The human body consists of many different types of tissues each with specific passive electrical properties. Vital activities lead to a characteristic change of these properties and geometrical changes. Magnetic induction is a non-contact method which can be used to determine these changes. The method is based on the creation of a primary magnetic field that will produce eddy currents in the ...
S. D. Evans, J. S. Roth, M. R. Cheetham
University of Leeds, Leeds, UK
Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...
Numerical Simulations Demonstrate Safe Vitrification and Warming of Embryos Using the Rapid-i™ Device
B.O.J. Johansson, Y.A. Tarakanov, H.J. Lehmann, and S.P. Apell
Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
Vitrolife Sweden AB, Västra Frölunda, Sweden
During cryopreservation of human embryos, ice crystal formation in the embryos or in surrounding media may cause cryodamage to them and can be lethal. A strategy to avoid this is the vitrification procedure when the embryo and the surrounding medium undergo the transition to glassy state rather than a crystalline one during cooling. Similarly, recrystallization in the embryo or the medium must ...
A. Gerisch, S. Tiburtius, Q. Grimal, and K. Raum
Technische Universität Darmstadt, Darmstadt, Germany
Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany
Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...
Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies
M.S. Yeoman, C. Quah, A. Cizinauskas, K. Cooper, D. McNally, B. Boszczyk
Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom
Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...
G. Zhang, S. Bearden
Clemson University, Clemson, SC, USA
It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...