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吴淑莲 [1], 李晖 [2], 李志芳 [2],
[1] 福建师范大学,福州,中国
[2] 福建师范大学,福州,中国

引言:激光诱导间质肿瘤热疗法是一种可使生物组织局部地方凝结坏死的肿瘤疾病治疗方法,目前已经用于肝、脑等各部位的肿瘤治疗[1-2]。为了更好地进行肿瘤疾病的治疗,需要实时地对组织的温度和热损伤进行监控,而检测技术很难实现对肿瘤治疗过程的实时监测,故数值计算成为研究光热疗法的有力工具[2-6]。本模型将生物组织光传输的物理场与热传输的物理场相耦合,考虑组织光热参数随温度变化的情况,研究了肿瘤周围含有大动脉的情况时组织的温度分布随时间的变化情况,研究结果对指导临床医学肿瘤治疗有重要意义。 COMSOL Multiphysics® 的软件使用: 几何模型:如图1所示,圆柱代表光源,圆形区域代表肝脏肿瘤,弯曲圆柱代表大血管,大正方体代表肝脏。 PDE 接口和生物传热接口,选择生物组织的热损伤。 结果: 如图2,图3所示,在加热过程中,开始时血管对温度分布几乎无影响,但是随着加热时间变长 ...

Analysis to Determine Optimum Strain Gauge Locations for SENSEWHEEL - new

T. Suzuki[1], C. Holloway[1], S. Taylor[1]
[1]University College London, London, UK

Manual wheelchair users suffer shoulder pain and injury in the long term because of unconscious overuse. The ‘SENSEWHEEL’, which interposes three identical load cells between pushrim and rear wheel, measures the three components of pushing force Fx, Fy and Fz, and axial torque Tx applied at each load cell. Strain gauges were located on a diaphragm forming one face of the load cell. The ...

Fluid Flow Behavior in Steady and Transient Force Medical Injection Systems

E. Gutierrez-Miravete [1], T. Langley [2],
[1] Rensselaer Polytechnic Institute - Hartford, Hartford, CT, USA
[2] Rensselaer Polytechnic Institute, Troy, NY, USA

Syringes were first conceptualized in 1650, but were invented in 1853 by Dr. Alexander Wood. As of 2011, nearly 8 billion syringes are used each year in the United States for medical purposes (not including veterinary services). These syringes are used for diseases like diabetes, rheumatoid arthritis, multiple sclerosis, and HIV. As injected medication is becoming increasingly more common, ...

Shear Stress Analysis in High-Throughput Dual-micropillar-based Microfluidic Platform

J.Borana[1], J.M.Lee[2], B.G.Chung[2]
[1]Indian Institute of Technology Guwahati, Guwahati, India
[2]Department of Mechanical Engineering, Sogang University, Seoul, Korea

We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...

Computational design and analysis of Microwave Tomography in Intracerebral Hemorrhage

Priyadarshini Natarajan [1], Rajkumar ElagiriRamalingam[1]
[1]Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India

Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...

Investigating the Loading Behaviour of Intact and Meniscectomy Knee Joints and the Impact on Surgical Decisions

M. S. Yeoman [1],
[1] Continuum Blue Ltd., Cardiff, United Kingdom

Knee joints are often subject to high loads, which can lead to injury, malalignment, and the progression of osteoarthritis in patients. To better understand the behavior, and the effect of meniscal damage and different meniscectomy repair approaches, a 3D structural mechanics model of a patient specific knee was developed in COMSOL Multiphysics®. The model made use of the Structural Mechanics ...

A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application

N. M. S. Bettahalli[1], B. J. Papenburg [2], D. S. Stamatialis [2], M. Wessling [3]
[1]University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
[2]University of Twente, Enschede, The Netherlands
[3]RWTH Aachen University

Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...

Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies

M.S. Yeoman[1], C. Quah[2], A. Cizinauskas[1], K. Cooper[1], D. McNally[5], B. Boszczyk[2]
[1]Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
[2]The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
[5]Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom

Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...

Modeling Plant Morphodynamics in Predefined COMSOL Multiphysics® Interface

S. Nikolaev[1], A. Trubuil[2]
[1]Institute of cytology and genetics SB RAS, Novosibirsk, Russia
[2]Institut National de la Recherche Agronomique, Jouy-en-Josas, France

We used a predefined COMSOL Multiphysics® interface to imitate biological growth and shape change (morphodynamics). We found a set of parameters that supply observed morphodynamics for an Arabidopsis embryo during its transition from globular to heart stage.

Influence of Non-Newtonian Blood Viscosity on Wall Pressure in Right Coronary Arteries with Serial Stenoses

B. Liu [1]
[1] Monmouth University, West Long Branch, NJ, USA

Three dimensional mathematical models are developed to simulate the blood flows in patient specific right coronary arteries with two stenoses. Simulations are carried out with various flow parameters under physiological conditions. Both Newtonian and non-Newtonian blood viscosity models are applied in the simulations to examine the influence of non-Newtonian viscosity of blood on the wall ...