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Time-Domain Model of the Inner Ear to Study Nonlinear Responses

K. Gladine [1], J. Soons [1], J. Dirckx [1]
[1] University of Antwerp, Belgium

The ear doesn’t solely listen but it also speaks. Sounds formed in the inner ear which are measurable in the outer ear are called Otoacoustic emissions (OAEs). Some claim these are produced by the outer hair cells (OHCs), the amplifiers in the inner ear. Our hypothesis is that the OHCs only amplify distortion products (DPs) but do not produce them.

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Modeling of Retinal Electrical Stimulation Using a Micro Electrode Array Coupled with the Gouy-Chapman Electrical Double Layer Model to Investigate Stimulation Efficiency

F. Dupont, R. Scapolan, C. Condemine, J.F. Bêche, M. Belleville, and P. Pham
CEA, LETI, Minatec, Grenoble, France

The electrical stimulation for retinal implant has known significant improvements in the last decades with many implantations and experimentations. The ability to create better controlled and adapted signals to increase the efficiency in stimulation is a major objective. The aim of this study is to develop a numerical platform based on COMSOL Multiphysics to simulate different waveforms. The ...

Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface

F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Palaiseau, France

Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...

Transport and Concentration of Charged Molecules in a Lipid Membrane - new

S. D. Evans[1], J. S. Roth[1], M. R. Cheetham[1]
[1]University of Leeds, Leeds, UK

Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Advanced Modeling of a Lung-on-a-Chip Microdevice

M. J. Hancock [1], N. H. Elabbasi [1],
[1] Veryst Engineering, Needham, MA, USA

Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and vascular perfusion of the body.[1] Such devices are being developed to provide better levels of tissue and organ functionality compared with conventional cell culture systems, and have great potential to ...

Simulations of Microelectrode and Neuron Interfaces Enable Long-Term and High Fidelity Recordings

P. Wijdenes [1], H. Ali [2], N. Syed [3], C. Dalton [2],
[1] Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
[2] Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
[3] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...

Blood Flow Patterns in a Patient Specific Right Coronary Artery with Multiple Stenoses - new

B. Liu[1]
[1]Department of Mathematics, Monmouth University, West Long Branch, NJ, USA

Atherosclerotic lesions preferentially develop in certain regions like bifurcations, branches, and bends [1, 2]. A possible explanation for such a preferential localization of atherosclerosis is that the geometry of the vessel influences the blood flow pattern. It suggests that the arterial geometry plays an important role in determining the localized blood flow information. Thus hemodynamic ...


吴淑莲 [1], 李晖 [2], 李志芳 [2],
[1] 福建师范大学,福州,中国
[2] 福建师范大学,福州,中国

引言:激光诱导间质肿瘤热疗法是一种可使生物组织局部地方凝结坏死的肿瘤疾病治疗方法,目前已经用于肝、脑等各部位的肿瘤治疗[1-2]。为了更好地进行肿瘤疾病的治疗,需要实时地对组织的温度和热损伤进行监控,而检测技术很难实现对肿瘤治疗过程的实时监测,故数值计算成为研究光热疗法的有力工具[2-6]。本模型将生物组织光传输的物理场与热传输的物理场相耦合,考虑组织光热参数随温度变化的情况,研究了肿瘤周围含有大动脉的情况时组织的温度分布随时间的变化情况,研究结果对指导临床医学肿瘤治疗有重要意义。 COMSOL Multiphysics® 的软件使用: 几何模型:如图1所示,圆柱代表光源,圆形区域代表肝脏肿瘤,弯曲圆柱代表大血管,大正方体代表肝脏。 PDE 接口和生物传热接口,选择生物组织的热损伤。 结果: 如图2,图3所示,在加热过程中,开始时血管对温度分布几乎无影响,但是随着加热时间变长 ...