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Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.

Assessment of Anterior Spinal Artery Blood Flow following Spinal Cord Injury

M. Alshareef[1], A. Alshareef[2], V. Krishna[3], M. Kindy[3], T. Shazly[4]
[1]College of Medicine, Medical University of South Carolina, Charleston, SC, USA
[2]Department of Biomedical Engineering, Duke University, Durham, NC, USA
[3]Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA
[4]Department of Mechanical Engineering, University of South Carolina, Columbia, SC, USA

The incidence of spinal cord injury (SCI) in the US is approximately 12,000 individuals annually, due to various forms of trauma and disease. Diminished flow over a prolonged period of time can cause permanent spinal damage. We constructed a 3D finite element model of the spinal cord to examine the role of compressive loading on spinal blood flow. It was found that the type of forces on the ...

The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes

G. Zhang[1][,][2][,][3], S.L. Bearden [1]
[1]Department of Bioengineering, Clemson University, Clemson, SC, USA
[2]Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
[3]Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA

Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...

Simulating Thermotherapeutic Response Induced by Thermal Padding for Treating Acute Injuries

J. Kantor[1], Y. Feng[1], C. Acosta[1], E. Massingill[1]
[1]University of Texas at San Antonio, San Antonio, TX, USA

Cryotherapy and thermotherapy are common methods of treatment for acute injuries ranging from ankle sprains to complex surgery. The idea behind such treatment is that a change in temperature will reduce pain and constrict fluctuations in blood flow at the targeted area. The purpose of this study is to simulate the vascularized tissue reaction and the resulting blood flow fluctuation from thermal ...

Microvascular Dysfunction in PAD Patients - new

K. Cluff[1], H. Mehraein[1], B. Jayakumar[2]
[1]Department of Bioengineering, Wichita State University, Wichita, KS, USA
[2]Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...

Fresh Produce Safety During Hydrocooling: An Engineering Model - new

A. Warning[1], A. K. Datta[1]
[1]Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA

Hydrocooling is the process by which warm produce is chilled with water. The chilling of warm produce generates a negative pressure differential between the produce (warm) and (cold) water due to the condensation of water vapor inside the produce which forms a vacuum and can pull in contaminated water through an opening. A porous media based model of water infiltration was developed using a ...

Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico

P. Wallin[1], E. Bernson[1], J. Gold[1]
[1]Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden

Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...

Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis

F.J. del Campo[1], A. Torrents[1], J. Mas[2], F.X. Muñoz[1]
[1]Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
[2]Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...

Optimization of 3D Layered Metal-Dielectric Stacks (MDS) for Near-Field Fluorescence Imaging

P.S. Tan[1], K. Elsayad[2], K. Heinze[1]
[1]Rudolf Virchow Center, University of Würzburg, Würzburg, Germany
[2]Research Institute of Molecular Pathology (IMP), Vienna, Austria

Nano-structures consisting of layered metal-dielectric stacks (MDSs) can be designed to have evanescent transmission and reflection coefficients that oscillate as a function of transverse wavevector and frequency. However, these structures always suffer from the material losses and surface roughness that are detrimental to image reconstruction. As such, we propose an optimized planar anisotropic ...

An Assessment of the Suitability of the Body and Adult Head Coils for Transmission during Paediatric Magnetic Resonance Imaging

G.R. Cook[1], M.J. Graves[1], F.J. Robb[2], D.J. Lomas[1]
[1]Department of Radiology, University of Cambridge, Cambridge, United Kingdom
[2]General Electric Healthcare Coils, Aurora, Ohio, USA

MRI offers many advantages over other modalities and its lack of ionizing radiation is important for children, but can be limited by the radio-frequency (RF) coils available. This work calculates Specific Absorption Rate (SAR) and homogeneity of the RF transmit field (B1+) when imaging infants in adult coils. Two birdcage-type coils were loaded by a tissue model and their B1+ homogeneities ...