R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
J. Martel, N. Elabbasi, D. Quinn, J. Bergstrom, M. Toner
BioMEMS Resource Center, Massachusetts General Hospital, Boston, MA, USA
Veryst Engineering, Needham, MA, USA
Inertial focusing is a promising microfluidic technique for separating and concentrating cells of interest, processes routinely utilized in many medical procedures. This phenomenon is characterized by suspended particles in a flow spontaneously migrating across streamlines to equilibrium positions within a channel cross-section. We developed CFD models in COMSOL Multiphysics® to predict the ...
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
A key challenge to finding quantitative solutions to biological problems is to model the complex 3D geometry of naturally occurring structures. Model generation often starts from serial sections from CT or MRI scans, confocal microscopy, or physical sectioning. In addition, prior to V4 of COMSOL Multiphysics®, there was a "loft" command to allow construction of 3D models from serial sections ...
M. Carfagna , A. Grillo ,
 Dipartimento di Scienze Matematiche, Politecnico di Torino, Italy
The numerical results of the unconfined compression test on a sample of Articular Cartilage (AC) are discussed. AC is modelled as a load-bearing, deformable, fiber-reinforced material filled with an interstitial fluid and comprising statistically oriented collagen fibers, chondrocytes, and a matrix of proteoglycans. A strain energy is assigned to characterize the mechanical behavior of the ...
J. Persad , S. Rocke , D. Ringis , A. Abdool ,
 Department of Electrical and Computer Engineering, University of the West Indies, St. Augustine, Trinidad and Tobago
3D printing as applied to the area of electronics manufacture covers a broad range of traditional printing technologies . The attraction in 3D printing lies in its potential to disrupt the traditional photolithographic/subtractive manufacturing line with simpler additive processes. Additive electronics manufacturing which utilises 3D printing techniques allow for fewer production steps and ...
Comparison of Finite Element and Monte Carlo Simulations for Inhomogeneous Advanced Breast Cancer Imaging
Y. Xu, and Q. Zhu
University of Connecticut, Storrs, CT, USA
Three-dimensional FEM method provided by COMSOL is used to model an inhomogeneous advanced breast tumor of different optical properties for outer layer and inner core in a semi-infinite medium. The running time of FEM by COMSOL for one source and 14 detectors is 17.658s and which of Monte Carlo (MC) is 91017s, 5154 times longer. The absorption distribution is reconstructed by born approximation. ...
A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System
G. Naldi, G. Aletti, P. Causin
Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...
Electro Thermal Performance Prediction of Radio Frequency Ablation System for Efficient Cancer Treatment
C. Thiagarajan, V. Gnanasekar
ATOA Scientific Technologies Pvt Ltd, Whitefield, Bangalore, Karnataka, India.
Perfint Healthcare Pvt. Ltd, T.Nagar, Chennai, India.
Cancer causes significant human deaths. Radiofrequency ablation is an encouraging procedure for cancer treatment. The objective is to demonstrate the multiphysics simulation methodology. This paper summarizes the problem , governing equations, methodology, assumptions, simulation results and discussion related to the thermal performance prediction of radio frequency ablation on a homogeneous ...
J.Borana, J.M.Lee, B.G.Chung
Indian Institute of Technology Guwahati, Guwahati, India
Department of Mechanical Engineering, Sogang University, Seoul, Korea
We developed the dual-micropillar-based microfluidic platform to control cellular behavior. The 4×4 dual micro-pillar based platform consists of 16 circular-shaped outer micropillars and 8 saddle shaped inner-micropillars. We simulated various shapes of inner micropillars to analyze the shear stress inside the inner micropillar. Therefore, this dual-micropillar-based microfluidic platform could ...
Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new
K. Cluff, H. Mehraein, G. Jayakumar
Bioengineering, Wichita State University, Wichita, KS, USA
Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...