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Temperature Excursions at the Pulp-Dentin Junction during the Curing of Light-Activated Dental Restorations

M. Jakubinek[1,2], C. Neill[1], C. Felix[3], R. Price[2,3], M. White[1,2]

[1]Departments of Chemistry and Physics, Dalhousie University, Halifax, NS, Canada
[2]Institute for Research in Materials, Dalhousie University, Halifax, NS, Canada
[3]Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS, Canada

Heat produced during the curing of light-activated dental restorations could damage the dental pulp. Given the prevalence of composite restorations and the importance of avoiding injury to the pulp, efforts should be made to minimize the temperature increase that occurs at the pulp-dentin junction during light-curing. In this investigation we develop and evaluate a COMSOL Multiphysics FEM tooth ...

Growth and Remodelling of Intracranial Saccular Aneurysms

A. Di Carlo[1], V. Sansalone[2], A. Tatone[3], and V. Varano[1]
[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
[3]DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy

We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...

Shear Induced Detachment Of Microorganisms Attached To A Plane Wall

B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France

We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...

Material Characterization Method Development: From Education to Design Optimization

C. Morgan[1], N. Kenkare[1], M. Williams[2], A. Peterson[2], and D. Williams[2]
[1]Alcon Eye Care Division of Novartis R&D, Duluth, GA
[2]Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA

Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...

Stochastic Modeling of Biological Systems – Ranking the Model Parameters of the Human Vocal Folds

D. Cook[1]
[1]New York University, New York, USA

Computational models of biological systems are becoming more and more common in medical research areas. Evidence of this can be found by examining the number of articles containing the term “finite element” in the expansive National Institutes of Health (NIH) digital research archive PubMed. Numerical modeling of biological systems allows the execution of “computational ...

Finite Element Analysis Approach for Optimization of Enzyme Activity for Enzymatic Bio-fuel Cell

Y. Song, and C. Wang
Florida International University, Miami, FL, USA

Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...

Design of Microneedle Array for Biomedicine

N. Mane[1], A. Gaikwad[1]
[1]Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India

Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...

Finite Element Analysis of Induced Electroosmotic Flow in Brain Tissue and Application to ex vivo Determination of Enzyme Activity

Y. Ou[1], A. Rupert[1], M. Sandberg[2], S. Weber[1]
[1]University of Pittsburgh, Pittsburgh, PA, USA
[2]University of Gothenburg, Gothenburg, Sweden

Ectopeptidases are commonly accepted to be a means of clearing active peptides. However, studies have shown that they can also regulate peptide activity. We have developed a technique of electrokinetic push-pull perfusion (Ek-PPP, Figure 1) to examine this largely unexplored mechanism of modulation of peptide function. We push the neuropeptide galanin through organotypic hippocampal slice ...

Wireless RF Digital System for Mouth-Embedded Multi-Sensor Communication

I.M. Abdel-Motaleb[1], J. Lavrencik [1]
[1]Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA

There is urgent need to monitor dental and oral diseases, such as tooth decay, gum diseases, and teeth grinding. Such monitoring can be achieved by embedding sensors in the mouth. This technique faces some difficulties. The first is how the power needed for the operation of the sensors and the associated electronic chips can be generated. This power can be generated using the pressure exerted by ...

Evaluation of Performance of Enzymatic Biofuel Cells with Microelectrode Arrays Inside a Blood Artery via Finite Element Approach

C. Wang[1], Y. Song[1]
[1]Florida International University, Miami, FL, USA

Enzymatic biofuel cells (EBFCs) are considered as a promising candidate for powering miniature implantable devices. In order to predict the performance in the human blood artery, we simulated a 3D EBFC chip with highly dense micro-electrode arrays. In this simulation using COMSOL Multiphysics®, we applied the 1) Michaelis Menten equation; 2) Nernst potential equation; 3) Navier Strokes velocity, ...