J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...
A. Avanzini, and G. Donzella
Department of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy
The mitral valve apparatus is a complex and refined mechanism located between the left atrium and the left ventricle of the heart which can manifest various kinds of pathologies. In order to support identification of potentially critical conditions resulting from some typical cardiosurgery operations, it is important to develop models of the mitral valve that enable prediction of both stress in ...
The Effect of Cartilaginous Rings on Deposition by Convection, Brownian Diffusion and Electrostatics
Luleå University of Technology, Luleå, Sweden
This paper presents a numerical study of the deposition of spherical charged nanoparticles caused by convection and Brownian diffusion in a pipe with a cartilaginous ring structure. The model is supposed to describe deposition of charged particles in the upper generations of the tracheobronchial tree of the human lung. The upper airways are characterized by a certain wall structure called ...
B. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...
M. Nebyla, M. Pribyl
Institute of Chemical Technology, Prague, Department of Chemical Engineering, Prague, Czech Republic
We introduce a mathematical model of signal transmission in simple epithelial layers. The mathematical model consists of reaction-transport equations for extracellular ligands, cellular receptors, ligand-receptor complexes and a ligand releasing protease. We consider diffusion and nonstationary convective transport of protein ligands in the extracellular space. The study was carried out using ...
I. Neitzel, U. Prüfert, and T. Slawig
Technische Universität Berlin / SPP 1253
Technische Universität Berlin / Matheon
Excellence Cluster The Future Ocean, Algorithmic Optimal Control - Oceanic CO2-Uptake/SPP 1253
An optimal control problem (OCP) is studied to a PDE of elliptic type as well as state constraints. The resulting optimality system contains two PDEs, one algebraic equation and the so called complementary slackness conditions, i.e. dual products between function spaces. At this point, different regularization techniques come into use. In this paper we introduce a Barrier method as one possible ...
Simulations of Heat and Mass Transport During Biomass Conversion Processes Using 3D Biomass Particle Models with Realistic Morphology and Resolved Microstructure - new
P. Ciesielski, M. Crowley, L. Thompson, B. Donohoe, D. Robichaud, A. Sanders, M. Nimlos, T. Foust
Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA
National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA
Quantum Electronics & Photonics Division, National Institute of Standards & Technology, Boulder, CO, USA
Predictive simulations of biomass conversion processes will improve their technical performance and reduce economic uncertainty surrounding industrialization of biofuels production. The majority of present conversion simulations treat the biomass feedstock with simplifying assumptions that neglect important characteristics that are unique to biomass particles. These characteristics, including ...
Image-Based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-Pulmonary Applications
F.K. Hermans, R.M. Heethaar, R.T. Cotton, and A. Harkara
VU University Medical Center, Amsterdam, The Netherlands
Simpleware Ltd., Exeter, United Kingdom
For medical diagnostic purposes there is an increasing need for non- (or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. This paper ...
Comparison of Computational Methods for the Estimation of the Dielectrophoretic Force Acting on Biological Cells and Aggregates in Silicon Lab-on-chip
S. Burgarella, F. Maggioni, and G. Naldi
STMicroelectronics, Agrate Brianza, Milan, Italy
Department of Mathematics, University of Milan, Milan, Italy
Dielectrophoresis is a method for cell manipulation in miniaturized devices exploiting the dielectric properties of cells and/or cellular aggregates suspended in a fluid and subjected to a high-gradient electric field. The mathematical expression of the force is obtained by a multipole expansion whose terms involve increasing power of the particle\'s radius. Three methods for the expression ...
Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new
K. Cluff, H. Mehraein, G. Jayakumar
Bioengineering, Wichita State University, Wichita, KS, USA
Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...