Keynote Video: Moving Beyond Simulation for Biopharma Applications

Brianne Costa March 21, 2018

Pablo Rolandi from Amgen delivered a keynote presentation at the COMSOL Conference 2017 Boston. The topic? How Amgen is moving beyond modeling and simulation for biopharma development. Rolandi shared five examples that illustrate this idea across both biologic and synthetic medicine applications. If you missed his presentation, you can watch a recording of the video and read the highlights of what he discussed here.


Edmund Dickinson January 26, 2018

Previously on the blog, we discussed why surfaces are sites of special chemical interest and discussed the theories used to describe reactions at surfaces, including when those surfaces are described within homogenized models of porous media. In this blog post, we’ll discuss how chemicals behave when they become attached to a surface by adsorption. Adsorption plays an essential role in many catalytic and sensing processes, so let’s consider how it can be built into your chemical models.


Caty Fairclough January 5, 2018

Steam reformers are commonly used for power and energy generation processes. To accurately analyze the performance of a steam reformer design, you need to be able to couple mass, energy, and flow equations. Using the COMSOL Multiphysics® software, you can set up a model of a steam reformer that represents its real-world behavior and operating conditions.


Ed Fontes December 26, 2017

You can easily describe composition- and temperature-dependent fluid properties using the thermodynamic properties database, available as of version 5.3a of the COMSOL Multiphysics® software. For reacting systems, the database computes enthalpy of formation and enthalpy of reaction. For fluid flow and heat and mass transfer, the database can compute viscosity, density, heat capacity, thermal conductivity, and diffusivity of liquids and gases. For systems with several phases, the thermodynamic properties database computes the composition of the phases at equilibrium.


Caty Fairclough December 21, 2017

You’re standing in a lab full of beakers containing different colored liquids. While it may look like something out of a cartoon, this is a lab for researching vanadium redox flow batteries (VRFBs). Unlike conventional batteries, the chemical energy in VRFBs is contained in liquid electrolytes that are stored in external tanks and pumped through the cell to convert to or from electrical energy. By advancing VRFB designs, engineers can improve grid energy storage and the reliability of renewable energy.


Rasmus Karlsson November 27, 2017

Wet chemical etching is used to form patterns on surfaces, with applications including the production of integrated circuits, MEMS devices, and pressure sensors. This process has been around for hundreds of years, and was a favorite method of Old Master Rembrandt van Rijn. The optimization of chemical etching was historically a matter of trial and error, but in this blog post, we’ll show how to model the process in the COMSOL Multiphysics® software.


Edmund Dickinson October 10, 2017

In a previous blog post, we discussed why surfaces are special in chemical reactors. In this blog post, we’ll see how surface area is maximized in reactor structures such as pellet beds, and how we can simply and accurately simulate fixed-bed reactors in spite of their local geometric complexity and the importance of microscopic diffusion.


Edmund Dickinson September 5, 2017

Precision machining and quality of surface finish are major concerns for manufacturers of metal parts. The promise of a contactless method to machine surfaces with submillimeter precision and a clean surface, on metals of almost any hardness, might seem too good to be true. However, such a method, pulsed electrochemical machining (PECM), was the focus of a detailed investigation using numerical modeling presented at the COMSOL Conference 2016 Munich.


Caty Fairclough August 16, 2017

Research shows that microgravity exposure has an effect on the human body, such as by suppressing immune cell activity. This phenomenon also affects cancer cell migration. Making use of this fact can lead to the identification of new therapeutic targets for metastatic cancer cells. In this blog post, we’ll discuss how a research team used the COMSOL Multiphysics® software to design a culturing system to study cancer cell migration in microgravity.


Caty Fairclough August 15, 2017

Zone electrophoresis separates different species in a sample into distinct well-resolved peaks, giving scientists the ability to analyze substances like proteins and nucleic acids. Improving this electrophoretic separation technique requires us to accurately model the transport and separation of these species. Here, let’s look at how the COMSOL Multiphysics® software can be used to simulate the movement of species during zone electrophoresis.


Edmund Dickinson July 13, 2017

In biophysics, electrochemistry, and the design of catalytic reactors, researchers and engineers exploit the special chemical and physical properties of solid surfaces involving both gas-solid and liquid-solid interfaces. This blog post discusses the basics of the kinetics of surface reactions at simple surfaces and how they can be modeled with the COMSOL Multiphysics® software. In a subsequent blog post, we will look at how mass transport and reaction kinetics at surfaces are described for homogenized porous media.




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