Using Simulation to Optimize Biopharmaceutical Processes

Bridget Cunningham | March 13, 2015

The biological and chemical processes behind the development of biopharmaceuticals have an important effect on product quality. With its ability to deliver quick results at a lower cost, simulation is a valuable resource in studying and optimizing these techniques. Learn how COMSOL Multiphysics can benefit your modeling of biopharmaceutical processes.

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Bridget Cunningham | February 24, 2015

Continuous stirred tank reactors (CSTRs), or ideal stirred tank reactors, are frequently used in the chemical and biochemical industries. This reactor type operates at steady state and because of its good mixing properties, it is assumed that the composition throughout the reactor is uniform. Using a new model in the Reaction Engineering interface, we can visualize the dynamics within an ideal system of tank reactors.

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Niklas Rom | February 13, 2015

Many exciting features for chemical engineering modeling were introduced in COMSOL Multiphysics version 5.0. In this blog post, I will discuss the most important updates. There are some new modeling interfaces, such as the Chemistry interface, and some that have been revamped and improved, like the Reaction Engineering interface. To begin with, I will recap the modeling interfaces for reaction engineering and mass transport.

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Ed Fontes | February 5, 2015

Starting the car on a cold winter morning can be unpleasant if you have not been proactive the night before. When you are unable to start an engine, it is often the battery’s fault. Why is a battery more sensitive than other processes in a car? The answer lies in the battery’s ability to convert chemical energy into electrical energy, with a minimum of heat generation, and the relatively small amounts of thermal energy available at low temperatures.

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Ed Fontes | February 3, 2015

Modeling of heterogeneous catalysis traditionally attracts great interest from the chemical engineering community, due to the many industrial processes that utilize this type of catalysis. Here, we discuss the procedure of starting with detailed micro-geometries and then proceeding with approximations through homogenization. By following this procedure, from the microscopic particle level to the macroscopic reactor level, we can design the catalyst in detail and study the influence of this design on the total reactor performance.

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Mikael Fredenberg | December 17, 2014

The printed circuit board (PCB) is the heart of almost any electronic product, carrying the components and copper wires supporting its functionality. The manufacture often involves electroplating, a process that can vary between designs. This leaves you, the engineer behind its simulation and optimization, constantly creating new models. What if you could push much of this work onto the designers, engineers, and technicians behind its design and manufacture, having them run their own electroplating simulations for PCBs? See how here.

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Ed Fontes | November 21, 2014

The Tubular Reactor application is a tool where students can model a nonideal tubular reactor, including radial and axial variations in temperature and composition, and investigate the impact of different operating conditions. It also exemplifies how teachers can build tailored interfaces for problems that challenge the students’ imagination. The model and exercise are originally described in Scott Fogler’s book Elements of Chemical Reaction Engineering. I wish I had access to this type of tool when I was a student!

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Niklas Rom | November 3, 2014

Probably the most common reactor in the chemical industry is the packed bed reactor. This reactor is used in chemical synthesis and for effluent treatment and catalytic combustion. Oftentimes, heterogeneous catalysis requires packed beds. A common design is a cylindrical column filled with catalyst pellets. The pellets can be contained within supporting structures, like tubes or channels, or packed in a single compartment in the column. The latter is called dumped packing.

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Bridget Cunningham | October 27, 2014

The design of the reactor used in hydrodealkylation can have a significant impact on the overall yield and selectivity of the conversion product. In this blog post, we use modeling and simulation to investigate the advantages of using a membrane reactor.

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Andrew Griesmer | October 15, 2014

For anyone interested in modeling chemical reactions and/or flow through porous media, we have created a video to demonstrate how COMSOL Multiphysics simulation software handles such applications. Consider this your interactive tour of the model documentation for our porous reactor model.

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Bridget Cunningham | October 9, 2014

In the performance of lithium-ion batteries, thermal management is an important element to consider. Through modeling and simulation, you can improve the design process by analyzing how heat is transferred within the energy source.

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